Proteina | Inhibitors of Apoptosis (IAP) Protein

A marker of cell apoptosis

The inhibitors of apoptosis (IAP) family proteins control cell death programs through an intricate protein-protein interaction (PPI) network, including a variety of caspases. IAP family proteins are occasionally amplified in cancers, leading to the evasion of apoptosis. Because of the high molecular heterogeneity of cancers, the IAP PPI network is rewired differently in individual cancer patients. Understanding the latest status of the IAP PPI network in a clinical sample facilitates selection of pharmacodynamic and predictive biomarkers for IAP antagonists.

Revealing new insight for biomarker discovery

We are developing assays that provide a comprehensive picture of the IAP PPI network specific to an individual sample. The reproducibility of our quantitative technology permits the accumulation of large-scale data for the IAP PPI network from many specimens, forming the basis of biomarker discovery for a given IAP antagonist. Our technology enables the discovery of biomarkers for estimating and improving the therapeutic performance of your compound.

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Inhibitors of apoptosis (IAP) protein family assays

A marker of cell apoptosis

Revealing new insight for biomarker discovery