SCIENCE

Pipeline

Target

Other targets

EGFR
HER2
HER3
MET
ER-α
ER-β
PR
AR
RET

FGFR1
FGFR2
FGFR3
FGFR4
IGF1R
TGF-βR
TNFR
VEGFR2
ALK

PD-1

PD-L1

CD28

CTLA-4

CD3

CD80

CD86

CD40

AXL

Actively
Ongoing
Targets

Hormone
Receptor
Targets

Immune
Targets

Probe

Grb2
p85a
p110a
Plc-g
AKT
Gab1
p70s6K
FRS2
JAK1
STAT3
STAT5B

KRAS
NRAS
HRAS
BRAF
CRAF
MEK
SOS1
SRC
SHC1
SPRY2
PDK1

CDK4
CDK6
CCDN1
SHP2
Fyn
Vav3
Cbl
SMAD2
SMAD3
Nck1
TRAF2

Cell cycle
probes

RTK
downstream
probes(1)

Actively
Ongoing
probes

Immune
Probes

Intracellular
Probes

RTK
downstream
probes(2)

Immune/

Tumor
dual probes

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